GenoPlast: Bayesian analysis of genome plasticity


Acquisition and loss of genetic material are essential forces in bacterial microevolution. They have been repeatedly linked with adaptation of lineages to new lifestyles, and in particular pathogenicity. GenoPlast implements a model-based method for using whole genome sequences to infer the patterns of genome content evolution. The method is described in Didelot, Darling and Falush (2009). A fundamental property of our model is that it allows the rates at which genetic elements are gained or lost to vary in time and from one lineage to another.


Before you start using GenoPlast, it would be very helpful if you could register by clicking here. This is optional, however this information is useful for us in planning possible future upgrades of the software. Registered users will also be kept informed of updates via email. Thank you.

Getting help

Click here to download the GenoPlast user guide in PDF format.

The paper describing the methods is also available: Didelot, Darling and Falush (2009)

If you have a question or a problem that is not discussed in the user guide, please get in touch.


Version 1.0 (Novermber 2008):

The input matrix required by GenoPlast can be generated from a Mauve backbone file using the utility bbFilter which is available here for Linux32, Linux64, Mac and Windows.